A possible method of inhibition of virus COVID-19 reproduction through induction of intra-cellular synthesis and upregulation of interferon

Research article: A possible method of inhibition of virus COVID-19 reproduction through induction of intra-cellular synthesis and upregulation of interferon 

Author: A.A. Mekhtiev

1Academician Abdulla Garayev Institute of Physiology, Azerbaijan National Academy of Sciences, 78 Sharif-zadeh Str., Baku AZ1100, Azerbaijan

For correspondence: arifmekht@yahoo.com

Received 08 October 2020; Received in revised form 11 November 2020; Accepted 13 November 2020

Abstract: 

The article substantiates studies on the inhibition of virus COVID-19 reproduction within the organ- ism based on upregulation of intracellular interferon I through strengthening synthesis and upregu- lation of heat shock protein with the molecular mass of 70 kDa.

Keywords: Virus COVID-19, heat shock protein 70 kDa, intra-cellular interferon upregulation

References 

Allahverdiyeva T.N., Mehdiyev Kh.Sh., Gaisina A.A., Mekhtiev A.A. (2019) Activation of  serotonergic system supports survival of animals of different species under bacterial and chemical toxins. J. Evolutionary Biochem. Physiol., 55(1): pp. 23-27.

Guseinov Sh. B., Mekhtiev A.A. (2013) Studies of the role of serotonin-modulating anticonsolidation protein in memory formation in rats in a shuttle box. Neurosci. Behav. Physiol., 43(5): 551-556. https://doi.org/ 10.1186/s12967-020- 02344-6.

Ismailova U.S., Mekhtiev A.A. (2018) Reparative mechanisms in retina and hypothalamus contributing to rhodopsin recovery in rabbit eyes with retinal dystrophy. Vestnik Oftalmologii, 134(5), Pt. 1: 39-46.

Jacquemin C., Rambert J., Guillet S., Thiolat D., Boukhedouni N., Doutre M.S., Darrigade A.S., Ezzedine K., Blanco P., Taieb A., Boniface K., Seneschal J. (2017) Heat shock protein 70 potentiates interferon alpha production by plasmacytoid dendritic cells: relevance for cutaneous lupus and vitiligo pathogenesis. British J. Dermatol. 177(5): 1367-1375.

Kawai T., Akira S. (2010) The role of patternrecognition receptors in innate immunity: Update  on toll-like receptors. Nat. Immunol. 11: 373-384.

Kono, H., Rock K.L. (2008) How dying cells alert the immune system to danger. Nat. Rev. Immunol., 8: 279-289.

Mantlo E., Bukreyeva N., Maruyama J., Paessler S., Huang Ch. (2020) Antiviral activities of type I  interferons to SARS-CoV-2 infection. Antiviral Research., 179: 104811.

Mekhtiev A.A. (2000) Revealing in the rat brain the protein possessing anticonsolidation properties. Bulletin Exper. Biol. Med., 129(8): 147-150.

Mekhtiev A.A., Allahverdiyeva T.N., Movsumzadeh S.K. (2017) DNA integrity-protecting and survival-promoting activity of serotonergic system in sturgeon juveniles and sazans. Fish Physiology and Biochemistry, 43(4): 1153-1160.

Mekhtiev A.A., Movsum-zadeh S.K. (2008) Anti-mutagenic activity of serotonergic system and underlying mechanisms in sturgeon juveniles (Acipenser gueldenstaedti persicus) and goldfish (Carassius auratus). J. Evol. Biochem. Physiol., 44(5): 476-481.

Mustafayev N.J., Mekhtiev A.A. (2014) Character of changes of serotonin-modulating anticonsolidation protein and cytochrome P-450 in the tissues of eastern alburnoid Alburnoides bipunctatus eichwaldi from rivers of Azerbaijan. J. Evolutionary Biochem. Physiol., 50(3): 190-195.

Pachetti M., Marini B., Benedetti F., Giudici F., Mauro E., Storici P., Masciovecchio1 C., Angeletti S., Ciccozzi M., Gallo R. C., Zella D., Ippodrino R. (2020) Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. J. Translat. Medicine, 18: 179.

Pardeshi Ch.V., Belgamwar V.Sh. (2013) Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood--brain barrier: an excellent platform for brain targeting. Expert Opin. Drug Deliv., 10(7): 957-972.

Smirnov V.M., Sveshnikov D.S., Tsirkin V.I. (2015) Serotonergic Nerves. Chekhov. Medical Informational Agency, 376 p. (in Russian).

Vabulas R.M., Wagner H., Schild H. (2002) Heat shock proteins as ligands of toll-like receptors. Curr. Top. Microbiol. Immunol., 270: 169-184.

Vanderheiden A., Ralfs Ph., Chirkova T., Upadhyay A.A., Zimmerman M.G., Bedoya Sh., Aoued H., Tharp G.M., Pellegrini K.L., Manfredi C., Sorscher E., Mainou B., Lobby J.L., Kohlmeier J.E., Lowen A.C., Shi P.-Y., Menachery V.D., Anderson L.J., Grakoui A., Bosinger S.E., Suthar M.S. (2020) Type I and Type III interferons restrict SARS-CoV-2 infection of human airway epithelial cultures. J. Virol.,  94(19): e00985-20. doi: 10.1128/JVI.00985-20.

Zhang Z., Zhang Z.Y., Wu Y., Schluesener H.J. (2012) Immunolocalization of toll-like receptors 2 and 4 as well as their endogenous ligand, heat shock protein 70, in rat traumatic brain injury. Neuroimmunomodulation, 19: 10-19.

 



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