Effects of fluoxetine on memory processes in the rats with different phenotypes of nervous system and different levels of biogenic monoamines of the brain
Research article: Effects of fluoxetine on memory processes in the rats with different phenotypes of nervous system and different levels of biogenic monoamines of the brain
Author: M.B. Majidi
Academician Abdulla Garayev Institute of Physiology, Azerbaijan National Academy of Sciences, 78 Sharifzadeh Str., Baku AZ1100, Azerbaijan;
For correspondence: sorena30@gmail.com
Accepted for publication: 17 April 2020
Abstract:
The present paper explores the effects of the psychopharmacological agent - fluoxetine - on mnestic processes, using a model of passive avoidance on male Wistar rats with different nervous system phenotypes and different activity ratios of the monoaminergic systems of the brains. In the re-test session under administration of fluoxetine, the seizure-tolerant rats compared to the seizure-sensitive rats were characterized by a more pronounced fear response to the "unsafe" compartment and en- hanced anxiety facilitating the retention of memory trace. The individual sensitivity of the animals to the action of fluoxetine and the direction of its effects on mnestic processes are supposed to be determined by different primary activity ratios of the monoaminergic systems of the brain.
Keywords: Seizure-tolerant and seizure-sensitive rats, passive avoidance response, fluoxetine, serotonin, dopamine, noradrenaline
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