The prescription of the vitamin D and biochemical tests in tumours of the female reproductive system

Research article: The prescription of the vitamin D and biochemical tests in tumours of the female reproductive system

Author (s):  V.Z. Khalilova*, A.Y. Qaziyev, G.A. Jafarova, N.V. Gasimov

Oncology Clinic of Azerbaijan Medical University, 208 S.Vurgun Str., Baku AZ1078, Azerbaijan

*For correspondence: vusala.xalilova77@gmail.com

Received: December 23, 2020; Received in revised form: March 17, 2021; Accepted: April 12, 2021 

Abstract

The results of a study conducted to compare the diagnostic role of vitamin D, calcium and phosphorus in patients with various tumours in the female reproductive system have been presented in this article. For the research, 50 women diagnosed with a tumour in the reproductive system were selected. The concentrations of vitamin D, parathormone (PTH), calcium and phosphorus were determined in all patients by immunoenzyme and biochemical methods. The concentration of vitamin D in patients with a malignant tumour was 2.2 fold higher than that in patients with a benign tumour. Moreover, the concentrations of the calcium and phosphorus in patients with a malignant tumour were significantly lower in comparison with the control group, while the concentration of PTH increased. Thus, these markers can be used for early diagnosis and screening of female genital tumours.

Keywords: Cancer of the female reproductive system, vitamin D, parathormone, calcium, phosphorus

References

Beller U., Quinn M.A., Benedet J.L., Creasman W.T., Ngan H.Y., Maisonneuve P., Pecorelli  S., Odicino F., Heintz A.P. (2006) Carcinoma of the vulva. FIGO 26th annual report on the results of treatment in gynecological cancer. Int. J. Gynaecol. Obs., 95 (Suppl. 1): S7–S27. 

Dobnig H., Pilz S., Scharnagl H. (2008) Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality. Arch. Intern. Med., 168: 1340–1349; doi: 10.1001/archinte.168.12.1340.

Gagel R.F. (1993) Mineral and vitamin D RDA for infants children and adults. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 2nd ed., Favus M.J. (ed.).  New York: Raven Press, 413 p.

Garland C.F., Mohr S.B., Gorham E.D., Grant W.B., Garland F.C. (2006) Role of ultraviolet b irradiance and vitamin D in prevention of ovarian cancer. Am. J. Prev. Med., 3: 512–514. 

Golden N.H., Abrams S.A. (2014) Committee on Nutrition optimizing bone health in children and adolescents. Pediatrics, 134: 1229-1243.

Holick M.F. (2007) Vitamin D deficiency. N. Engl. J. Med., 357 (3): 266–281: doi: 10.1056/NEJMra070553.

Kobyakova O.S., Deev I.A., Tyufilin D.S., Kulikov E.S. (2015) Vitamin D - a new vector of cancer prevention? Bulletin of the RAMS, No. 5: 526-533 (in Russian).

Lappe J.M., Travers-Gustafson D., Davies K.M., Recker R.R., Heaney R.P. (2007) Vitamin D and calcium supplementation reduces cancer risk: Results of a randomized trial. Am. J. Clin. Nutr., 85: 1586–1591.

Lurie G., Wilkens L.R., Thompson P.J., McDuffie K.E., Carney M.E., Terada K.Y., Goodman M.T. (2007) Vitamin D receptor gene polymorphisms and epithelial ovarian cancer risk. Cancer Epidemiol. Biomark. Prev., 16: 2566–2571. 

Maltsev S.V., Arkhipova N.N., Shakirova E.M. (2012) Vitamin d, calcium and phosphates in healthy children and in pathology. Kazan: 120 p. (in Russian). 

Parkin D.M., Bray F., Ferlay J., Pisani P. (2002) Global cancer statistics. CA Cancer J. Clin., 55: 74–108. 

Rastogi A., Bhadada S.K., Bhansali А. (2013) Pseudoarthrosis and fracture: interaction between severe vitamin D deficiency and primary hyperparathyroidism. Singapore Med. J., 54 (11): 224–227. 

Reichrath J., Rafi L., Muller S.M., Mink D., Reitnauer K., Tilgen W., Schmidt W., Friedrich M. (1998) Immunohistochemical analysis of 1,25-dihydroxyvitamin D3 receptor in cervical carcinoma. Histochem.  J., 30: 561–567. 

Siegel R.L., Miller K.D., Jemal A. (2017) Cancer statistics. CA Cancer J. Clin., 67: 7–30. 

Turti T.V., Belyayeva I.A., Bokuchava E.G., Privalova T.E., Gorbacheva A.A. (2017) The relevance of hypovitaminosis prevention in infants. Vopr. Sovrem. Pediatr., 16(2): 131-141 (in Russian). doi: 10.15690/vsp. v16i2.1714.

Walentowicz-Sadlecka M., Sadlecki P., Walentowicz P., Grabiec M. (2013) The role of vitamin D in the carcinogenesis of breast and ovarian cancer. Ginekol. Polska, 84: 305–308.

Zakharova I.N., Yablochkova S.V., Dmitriyeva Yu.A. (2013) Known and unknown effects of vitamin D. Vopr. Sovrem. Pediatr., 12(2): 20-25 (in Russian).

 

 

 

 


Добавить комментарий

Оставить комментарий

reload, if the code cannot be seen