Effects of saffron (Crocus sativus L., Iridaceae) on the testosterone level in the blood and sexual behaviour of male rats
Research article: Effects of saffron (Crocus sativus L., Iridaceae) on the testosterone level in the blood and sexual behaviour of male rats
Authors: U.F. Hashimova*, Kh.F. Babayev, P.A. Shukurova, S.I. Gasanova
Academician Abdulla Garayev Institute of Physiology, Azerbaijan National Academy of Sciences, 78 Sharifzadeh Str., Baku AZ1100, Azerbaijan;
* For correspondence: ulduz.hashimova@science.az
Accepted for publication: 10 April 2020
Abstract: The aim of the present research was to study the effects of Azerbaijan-grown saffron Сrocus sativus L. Iridaceae on the testosterone level in the blood and sexual behaviour of normal male rats. The data obtained showed that saffron increased the blood testosterone level as compared to untreated controls, which did not receive saffron. Per os administration of saffron also led to marked stimulation of the proseptive and receptive components of the sexual behavior in male rats.
Keywords: Saffron extract, sex hormones, testosterone, sexual behaviour, male rats, phyto-geroprotector
References:
Anisimov V.N. (2008) Molecular and physiological mechanisms of aging. St. Petersburg: Nauka, 481 p.
Buresh Ya., Bureshova O., Houston D.P. (1991) Techniques and basic experiments in the study of the brain and behavior. M.: 398s.
Gashimova U.F., Babaev Kh.F., Sadykh-zade R.A. Shukyurova P.A. (2016) Potential geroprotective properties of saffron (Crocus sativus, L.). Physician, 6:35-38.
Gashimova U.F., Kamilova N.K., Babaev Kh.F., Shukyurova P.A., Gasanova S.I., Abbasov R.Yu. (2017) Effect of saffron (Cro-cus sativus L. Iridaceae) on the level of follicle-stimulating hormone in the blood of female rats, the number of offspring and body weight dynamics in rat pups. Advances in Gerontology, 30(3): 436-441.
Directive 2010/63/EU of the European Parliament and Council of the European Union on the protection of animals used for scientific purposes (2012). St. Petersburg: 48 p.
Kasumov F.Yu., Nesrullaeva G.M., Abdullaeva I.M. (2002) Biological characteristics and chemical composition of saffron. Actual problems of ophthalmology. Baku, p. 95-97.
Kolman Ya., Rem K.-G. (2009) Visual biochemistry (translated from German). M.: Mir.
WHO monographs on medicinal plants widely used in the Newly Independent States (NIS) (2010) Ed. World Health Organization: 464 p.
Abdullayev F.I. (1993) Biological effects of saff-ron. BioFactors, 4: 83-86.
Agmo A. (1997) Male rat sexual behavior. Brain Res. Brain Res. Protoc., 1 (2): 203–209.
Agha-Hosseini M., Kashani L., Aleyaseen A.et al. (2008) Crocus sativus L. (saffron) in the tre-atment of premenstrual syndrome: a double-blind, randomized and placebo-controlled trial. BJOG, 115 (4): 515-519.
Akhondzadeh S., Fallah-Pour H., Afkham K.et al. (2004) Comparison of Crocus sativus L. and imipramine in the treatment on mild of moderate depression: a pilot double-blind randomized trial [ISRCT N 45683816]. BMC Complement Al-tern. Med., 2: 6771.
Ai J., Nekooeian A.A., Takhshid M.A., Mosta-fizi N. et al. (2009) Effect of aqueous extract of Crocus sativus L. (Saffron) stigma on serum le-vels of gonadotropins and folliculo-genesis in adult rats. Journal of Applied Animal Research, 35: 49-52.
Georgiadou G, Tarantilis PA, Pitsikas N. (2012) Effects of the active constituents of Cro-cus Sativus L., crocins, in an animal model of obsessive-compulsive disorder. Neurosci. Lett., 528 (1):27-30.
Heidary M., Vahhabi S., Reza Nejadi J. et al. (2008) Effect of saffron on semen parameters of infertile men. Urol. J., 4 (5): 255-259.
Hosseinzadeh H., Zeall T., Sadeghi A. (2008) The effect of saffron, Crocus sativus stigma, extract and its constituents safranal and crocin on sexual behaviors in normal male rats. Phyto-medicine, 15 (6-7): 491-495.
Modaresi M., Messripour M., Asadi Marghma-leki M. et al. (2008) Effect of saffron (Сrocus sativus) extract on level of FSH, LH and testos-terone in mice. ZUMS Journal, 16 (63): 11-18.
Shamsa A., Hosseinzadeh H., Molaei M. et al. (2009) Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. Phytomedicine, 8 (16): 690-693.
Svendsen K., Schultz A. (2008) Seksuell dysfunksjon hos men. Tidsskrift Norsk Legefore-ning, 128: 448-452.
Verma S.K., Bordia A. (1998) Antioxidant pro-perty of Saffron in man. Indian J. Med. Sci., 52 (5): 205-207.
Wu D., Gore A.C. (2010) Changes in androgen receptor, estrogen receptor alpha, and sexual be-havior with aging and testosterone in male rats. Norm. Behav., 58 (2): 306-316.