Morphology of lymph nodes and lymphocytes of peripheral blood during acute hypobaric hypoxia
Research article: Morphology of lymph nodes and lymphocytes of peripheral blood during acute hypobaric hypoxia
Author: S.M. Yagubova
Department of Pathological Anatomy, Azerbaijan Medical University, 14 A.Gasimzade Str., Baku AZ 1022, Azerbaijan;
*For correspondence: syagubova.71@gmail.com
Accepted for publication: 15 May 2020
Abstract:
The article provides information about the research work carried out to study the characteristic features of morphofunctional changes occurring in the mesenteric lymph nodes and lymphocytes of peripheral blood during acute barocamera hypoxia. The study was conducted on adult male white rats with a mass of 180-200 grams. Healthy animals included in control group were not intervened, respectively acute hypoxia model was established on the II group of animals. 2 and 5 days after the experiment, the mesenteric lymph nodes were taken from the peritoneal cavity, blood from the tail vein of the animals. Mesenteric lymph nodes and peripheral blood indicators were studied using histological and morphometric methods of examination. Conducted studies have shown that in acute hypoxia, sufficient structural-functional changes of systemic character occur in lymphoid organs. At an early stage of the experiment, these changes are of a nonspecific «stress» nature, transient neutrophil leukocytosis, eosinopenia and the formation of temporary lymphopenia lead to the development of involutive-cell dystrophy, thereby initiating the first phase – mobilization phase, characterized by a decrease in adaptation intensity.
Keywords: Acute hypobaric hypoxia, mesenterica lymph node, lymphocyte, follicle, structure
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