Study of changes in basic biochemical indicators of blood in the dynamics of development of modified alloxan diabetes in rats
Research article: Study of changes in basic biochemical indicators of blood in the dynamics of development of modified alloxan diabetes in rats
Author: Kh.R. Akhundova
Research Center and Department of Family Medicine, Azerbaijan Medical University,
Baku, Azerbaijan
Abstract: The article presents data on biochemical changes in the blood of experimental rats on the background of modified alloxan diabetes in dynamics. At the same time, there is a violation of the balance between the prooxidant system and the antioxidant defense system in the body, which is accompanied by insulin defi-ciency in varying degrees of severity. The arising oxidative stress in diabetes is a vicious cycle in connection with an increase in the sources of free radical formation, a weakening of the activity of the antioxidant system, which leads to tissue damage. Oxidative stress is accompanied by a decrease in the absorption and consumption of glucose by adipose tissue, impaired insulin secretion by β-cells, an increase in the rate of lipid peroxidation, which results in metabolic syndrome.
Keywords: alloxan trihydrate, diabetes mellitus, experimental rats, blood biochemistry
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