The role of neurochemical systems of the brain in the regulation of the hippocampal theta-rhythm

Research article:  The role of neurochemical systems of the brain in the regulation of the hippocampal theta-rhythm

Author: R.M. Baghirova

Azerbaijan State Academy of Physical Education and Sport, 98a Fatali Khan Khoyski Str., Baku AZ 1072, Azerbaijan;

For correspondence:

Accepted for publication: 03 April 2020


In chronic experiments on the rabbits it has been shown that electric destruction of the dorsal amyg- dalo-fugal pathway leads to complete and persistent blockade of hippocampal theta rhythm in cont- rast to the ventral amygdalo-fugal pathway. In intact animals, electro- and chemostimulations of vari- ous limbic structures of the brain (amygdala, hypothalamus, reticular formation, medial septum nuc- leus) lead to the formation of well pronounced theta rhythm in the hippocampus, but after destructi- on of the dorsal amygdalo-fugal pathway no theta-rhythm in this structure was observed. Restoration of hippocampal EEG took place under the intra-hippocampal application of carbocholine and strychnine. It is proposed that one of the necessary conditions for the regulation of excitability of hip- pocampal neurons is the integrity of the dorsal amygdalo-fugal pathway through which the regula- tory influences of the amygdala on the hypothalamic neuro-secretory cells are realized.

Keywords: Hippocampal theta-rhythm, dorsal and ventral amygdalo-fugal pathways, electrical and che- mo-stimulation, destruction


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